Abcam, ab51243, Anti-ARPC5/p16 ARC antibody [EP1551Y]

Size: 20µL / 100µL / 1mL
Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) is a rabbit monoclonal antibody detecting ARPC5/p16 ARC in Western Blot, IP, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Clone EP1551Y is the most cited clone to ARPC5/p16 ARC - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 150 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1551Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody is specific to the p16 ARC protein, database link:O15511. There is no observed cross reactivity to the CDKN2A/p16INK4a protein.

Product details:
Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P, IP, WB in human, mouse, rat samples.
Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has been cited over 158 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
The specificity of Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has been confirmed by testing in knockout samples.
Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has 5 independent reviews from customers.
Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) specifically detects ARPC5/p16 ARC (UniProt ID: O15511; Molecular weight: 16kDa) and is sold in 100 µL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone EP1551Y -
ab220800
Antibody clone EP1551Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 594, PE, APC, Alexa Fluor® 750 (
ab320122
ab320123
ab320124
ab320125
ab320126
ab320127
ab321644
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARPC5 also known as p16 ARC is a protein with a molecular weight of roughly 16 kilodaltons. It localizes largely in the cytoplasm and expresses in many cell types across species. The ARPC5 protein is a subunit of the Arp2/3 complex a vital component responsible for actin nucleation and branching during cytoskeleton remodeling. Researchers often examine ARPC5 through techniques such as western blot and immunohistochemistry using specific antibodies like anti-p16 or ARPC5 anticuerpo to identify its presence and distribution.
Biological function summary
The ARPC5 protein is essential for effective actin polymerization making it an important contributor to cell motility and structure. As part of the Arp2/3 complex it interacts with other proteins to stimulate the growth of new actin filaments. This activity is important in processes like endocytosis phagocytosis and cell migration. Furthermore ARPC5 plays a role in maintaining cellular homeostasis and is involved in cellular signaling pathways.
Pathways
Arpc5 influences the regulation of the actin cytoskeleton which intersects with pathways associated with cell movement and morphogenesis. It prominently relates to the WAVE complex working synergistically to regulate actin dynamics. ARPC5's involvement in the Rac1-WAVE-Arp2/3 pathway highlights its relationship with Rac1 a small GTPase known for regulating the cytoskeleton and cellular functions like adhesion and migration.
Imbalances in ARPC5 function can link to cancer progression and neurodegenerative diseases. Aberrant activity of the Arp2/3 complex which involves ARPC5 associates with increased cell invasion and metastasis in cancer. Additionally disruptions in ARPC5 activity connect to neurodegenerative conditions where cytoskeletal arrangement alterations play a role. The protein's interaction with others in the complex such as Rac1 further deepens its involvement in these diseases signaling potential targets for therapeutic intervention.