Abcam, ab52182, Anti-Bik antibody

Size: 100µg
Rabbit Polyclonal BIK antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human BIK.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BIK. The exact immunogen used to generate this antibody is proprietary information.Q13323

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Bik also known as Bcl-2-interacting killer is a pro-apoptotic member of the Bcl-2 family proteins. It is a small protein with a molecular mass of around 13 kDa. Bik expression occurs mainly in epithelial tissues but can also be found in endothelial cells. As a member of the Bcl-2 family Bik functions by interacting with anti-apoptotic proteins in the same family leading to the promotion of apoptosis through mitochondrial outer membrane permeabilization.
Biological function summary
Within cellular apoptotic pathways Bik acts as a regulator of programmed cell death. It becomes part of a greater complex involved in mitochondrial signaling to initiate apoptosis. Once it binds to anti-apoptotic proteins Bik releases cytochrome c from the mitochondria triggering caspase activation. This liberation results in the execution of the apoptotic process fundamental to many cellular systems including development and immune response.
Pathways
Bik plays a critical role in the intrinsic (mitochondrial) apoptotic pathway. Bik displays connections with several important anti-apoptotic proteins such as Bcl-2 and Bcl-xL. Through its function Bik is engaged in the regulation of cell survival and death impacting processes like tissue homeostasis and response to cellular stress. Other proteins such as Bax and Bak also align with Bik's pathway by promoting apoptosis once liberated from inhibition.
Bik has implications in cancer and neurodegenerative disorders. Its dysregulation can result in the avoidance of apoptosis leading to tumor development particularly in cancers like breast and colorectal cancer. Additionally in neurodegenerative diseases improper Bik activity can contribute to cell death. Bik influences these conditions through interactions with proteins like Bcl-2 which inhibit apoptosis highlighting the importance of Bik in therapeutic strategies that aim to restore apoptosis in disease contexts.