Abcam, ab52619, Anti-PPP1CA + PPP1CB antibody [EP1511Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PPP1CB antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1511Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IP, ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The immunogen for this antibody is 100% homologous with Human PPP1CA and PPP1CB

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein targets PPP1CA and PPP1CB also known as protein phosphatase 1 catalytic subunits alpha and beta function as serine/threonine phosphatases. They both play roles in a range of cellular processes. The molecular weight of PPP1CA is approximately 37 kDa while PPP1CB is around 38 kDa. These phosphatases express widely across various tissues including the brain muscle and liver contributing to their involvement in diverse cellular functions. Their distribution suggests a broad range of activities across different physiological systems.
Biological function summary
Protein phosphatase 1 catalytic subunits like PPP1CA and PPP1CB regulate important processes such as cell division and glycogen metabolism. These subunits typically are part of larger multiprotein complexes allowing for specific substrate targeting. By dephosphorylating specific proteins they act as regulatory signals within cellular systems influencing numerous biochemical pathways and responses. In neuronal tissues for example these phosphatases impact learning and memory by regulating synaptic plasticity through dephosphorylation cycles.
Pathways
These phosphatase subunits engage in the MAP kinase and PI3K-Akt signaling pathways. In the MAP kinase pathway they interact with proteins such as ERK helping regulate cell proliferation and differentiation. In the PI3K-Akt pathway they modulate the activity of key components influencing processes like cell survival and growth. The regulatory function of PPP1CA and PPP1CB within these pathways facilitates critical cellular responses to various extracellular signals thereby affecting the overall cellular physiology.
Alterations in PPP1CA and PPP1CB activity have links to several health concerns including cancer and diabetes. In certain cancers abnormal expression or mutation of these phosphatases affects cell cycle control leading to unchecked cell growth. In diabetes PPP1CA and PPP1CB influence glycogen metabolism where their dysregulation contributes to impaired glucose homeostasis. These targets connect to other proteins like GSK-3 in cancer and AKT1 in diabetes highlighting their diverse interactions and potential as targets for therapeutic intervention.