Abcam, ab52622, Anti-IRS4 antibody [EP907Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal IRS4 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP907Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The insulin receptor substrate 4 (IRS4) is a protein that plays a significant role in transmitting signals from insulin and insulin-like growth factor receptors to downstream pathways. It has a molecular mass of approximately 130 kDa. IRS4 is mainly expressed in the hypothalamus pituitary gland and several other organs such as liver and adipose tissues. IRS4 interacts with various signaling intermediates through its phosphotyrosine-binding domains therefore acting as a docking protein that facilitates signaling cascades.
Biological function summary
The role of IRS4 extends beyond signal transduction. It participates in the regulation of growth survival and metabolism. Although not part of a permanent protein complex IRS4 temporarily binds to receptors and adaptor proteins during signal transduction processes. The interactions allow IRS4 to integrate signals from different receptors to produce coordinated cellular responses particularly in energy homeostasis and glucose metabolism.
Pathways
IRS4 serves important functions in the insulin signaling and growth hormone signaling pathways. Within the insulin signaling pathway IRS4 acts as a central node linking insulin receptors to the activation of phosphoinositide 3-kinase (PI3K) which subsequently leads to activation of protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) pathways. Related proteins in these cascades include other insulin receptor substrates such as IRS1 and IRS2 which share overlapping roles but may exhibit tissue-specific functions.
IRS4 exhibits associations with metabolic conditions such as diabetes and obesity. Alterations in IRS4 expression or function can disrupt normal insulin signaling contributing to insulin resistance and metabolic dysregulation. IRS4 also shows connectiveness with proteins like PI3K and AKT which are frequently implicated in these metabolic disorders. Dissection of IRS4's role could potentially offer insights for therapeutic strategies targeting these diseases.