Abcam, ab52642, Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker

Size: 20µL / 100µL / 1mL
Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) is a rabbit monoclonal antibody detecting S100 beta in Western Blot, IHC-P, IHC-Fr, ICC/IF . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 390 publications - Trusted since 2007
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1576Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IF, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-Fr IHC-P and WB.
Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) was first used in a scientific publication in 2009 and has been cited over 399 times in peer reviewed journals. It's performance in IHC in mouse and human samples is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) has 35 independent reviews from customers.
Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) specifically detects S100 beta (UniProt ID: P04271; Molecular weight: 11kDa) and is sold in 100 µL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone EP1576Y -
ab215989
Antibody clone EP1576Y is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor
647, Alexa Fluor
594, Alexa Fluor
488, Alexa Fluor
555, Alexa Fluor
ab195535
ab196175
ab307851
ab310990
ab313219
ab313817
S100B is a calcium-binding protein widely used in neuro research, particularly for its role as a biomarker in neurological diseases. It is expressed in glial cells and certain neurons and its levels can indicate brain injury and neuroinflammation. Researchers use S100B to assess glial activation and neuronal damage in conditions such as traumatic brain injury, stroke and neurodegenerative diseases (e.g. Alzheimer's disease). This makes S100B essential for understanding the extent of brain damage and the inflammatory response in various neurological disorders.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein S100 beta also known simply as S100B is a member of the S100 protein family which consists of low-molecular-weight proteins characterized by the presence of two EF-hand calcium-binding motifs. It has a mass of approximately 10.7 kDa. S100 beta is abundantly expressed in astrocytes oligodendrocytes and Schwann cells within the central nervous system and is also found in a variety of other tissues. Additionally the protein often serves as a beta marker in these cells and plays a role in regulating intracellular calcium levels and cell proliferation.
Biological function summary
The functions of S100 beta involve modulating a range of cellular processes such as the dynamics of cytoskeleton cell growth and differentiation. It does not act alone but often forms homodimers or heterodimers and engages with target proteins influencing their activity. The expression and release of S100 beta can affect neuron growth and survival which makes it notable as one of the astrocyte markers used in immunohistochemistry to study neural tissue and brain injury responses.
Pathways
Research has shown that S100 beta actively participates in the regulation of important signaling pathways including the ERK and NF-κB pathways. These pathways are involved in various cellular responses like inflammation and cell survival. In its signaling roles S100 beta functions in connection with proteins like the receptor for advanced glycation end-products (RAGE) helping to transmit extracellular signals into the cell.
S100 beta has become associated with certain neurodegenerative diseases and cancer. Elevated levels of S100 beta have been observed in patients with Alzheimer's disease where the protein is believed to influence tau phosphorylation and amyloid-beta formation alongside interactions with proteins like tau. In the context of melanoma S100 beta serves as a marker indicating tumor progression and its interactions with proteins involved in cellular proliferation highlight its role in the disease process.