Abcam, ab53094, Anti-MGLUR8 antibody

Size: 100µg
Rabbit Polyclonal MGLUR8 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GRM8.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GRM8. The exact immunogen used to generate this antibody is proprietary information.O00222

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab53094 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The metabotropic glutamate receptor 8 (mGluR8) also known as GRM8 is a G-protein coupled receptor with an approximate molecular mass of 105 kDa. This receptor is involved in neurotransmitter signaling and plays a significant role in synaptic transmission by regulating the release of neurotransmitters. mGluR8 is mostly expressed in the brain specifically in regions related to sensory perception and modulation such as the retina olfactory bulb and various other brain areas.
Biological function summary
MGluR8 impacts neuronal excitability by modulating synaptic plasticity. It is often found as part of a dimerized complex with other mGluR proteins affecting intracellular signaling cascades. The receptor functions largely through inhibition of the cyclic AMP pathway making it a critical regulator in glutamatergic signaling. mGluR8’s activity serves as an important control point for maintaining the balance of excitatory neurotransmission within the central nervous system.
Pathways
MGluR8 is intricately connected to glutamatergic synaptic transmission and the cAMP signaling pathway. Through its role in these pathways mGluR8 interacts with proteins such as adenylate cyclase and other mGluR family members modulating downstream signaling events. These interactions position mGluR8 as an important element in neural communication processes influencing learning and memory functions.
MGluR8 has been associated with neurodegenerative diseases like Alzheimer's and psychiatric disorders such as anxiety. Its regulatory role in glutamatergic neurotransmission links it to pathologies characterized by excitotoxicity and altered synaptic plasticity. Interactions between mGluR8 and other proteins like presenilin-1 in Alzheimer's disease shed light on its potential as a therapeutic target for modulating disease progression.