Abcam, ab53724, Anti-pan Sodium Channel antibody

Size: 100µg
Rabbit Polyclonal SCN1A antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SCN1A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SCN1A. The exact immunogen used to generate this antibody is proprietary information.P35498,
Specificity:Detects endogenous levels of total sodium channel protein.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The pan Sodium Channel also known as alpha codium channel functions as a voltage-gated ion channel important for conducting sodium ions across cell membranes. These channels have different subtypes with varying molecular masses usually around 260 kDa. They are extensively expressed in neurons muscle cells and cardiac tissues contributing to the excitable characteristics of these cells. By regulating ionic gradients and membrane potentials pan Sodium Channels have an essential role in action potential initiation and propagation.
Biological function summary
Pan Sodium Channels play a central role in generating and conducting electrical signals in excitable tissues. They facilitate the rapid influx of sodium ions important for depolarization during action potentials. While not part of a larger protein complex these channels directly influence the activity of other cellular mechanisms like sodium-potassium pumps that restore ion gradients. Pan Sodium Channels have essential roles in muscle contractions and signal transmission in neurons.
Pathways
Pan Sodium Channels participate significantly in the action potential and cardiac conduction pathways. Their activity influences the nervous system signal transmission and cardiac rhythm maintenance. In cardiac tissues pan Sodium Channels work alongside potassium and calcium channels to maintain rhythmic contractions. They align with proteins like Nav1.5 in cardiac tissues integrating their function into synchronized electrical signaling necessary for heartbeats.
Mutations or dysfunctions in pan Sodium Channels often associate with neurological and cardiac diseases. Epilepsy stands out as a condition linked to sodium channel abnormalities leading to enhanced neuronal excitability. In cardiac contexts long QT syndrome involves these channels with associated proteins like Nav1.5 playing a significant role in the disorder's pathophysiology. Abnormalities in sodium channel activity can consequently trigger significant clinical implications in the nervous and cardiac systems.