Abcam, ab53796, Anti-PARP9 antibody

Size: 50µg
Rabbit Polyclonal PARP9 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human PARP9.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PARP9. The exact immunogen used to generate this antibody is proprietary information.Q8IXQ6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody is epitope affinity purified from rabbit antiserum., Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PARP9 also known as ADP-ribosyltransferase diphtheria toxin-like 9 is a protein involved in cellular DNA repair and immune response. The protein has a molecular mass of approximately 88 kDa. It is notably expressed in various tissues including lymphoid tissues and immune cells suggesting a role in the immune system. PARP9 possesses domains that may facilitate interactions with other proteins playing a part in regulating cellular repair processes.
Biological function summary
PARP9 enhances DNA repair mechanisms and modulates the immune response. It may work as part of larger protein complexes coordinating with other proteins to maintain genomic stability and regulate transcription. Its involvement in these complexes indicates a supportive role in cellular defense ensuring the integrity of genetic information and proper immune function. Moreover PARP9 may influence signal transduction pathways related to inflammation and cell survival.
Pathways
PARP9 participates in critical networks that govern DNA damage response and immune signaling. It aligns with the NF-kB pathway which controls transcription of DNA cytokine production and cell survival. Additionally PARP9 associates with the innate immune response pathway influencing processes driven by related proteins like STAT1 enhancing the cellular response to external stressors. These interactions reflect its contribution to cellular adaptation and resilience.
PARP9 links to conditions with underlying inflammatory or immune-related components. Its dysregulation associates with autoimmune diseases where it may influence abnormal immune activity. Additionally PARP9 has connections to certain cancers potentially through interactions with proteins like STAT3 which influences cell proliferation and survival. Understanding PARP9's role in these conditions could guide therapeutic strategies targeting abnormal protein interactions and signaling.