Abcam, ab5392, Anti-MAP2 antibody - Neuronal Marker

Size: 25µL
Anti-MAP2 antibody (ab5392) is a chicken polyclonal antibody detecting MAP2 in Western Blot, IHC-P, ICC/IF . Suitable for Mouse, Rat . - Over 780 publications - Trusted since 2003
Key facts
Host species:Chicken,
Clonality:Polyclonal,
Isotype:IgY,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAP2. The exact immunogen used to generate this antibody is proprietary information.P11137

Product details:
Find all reagents to label mature neurons in our "
Mature neuron markers guide
Anti-MAP2 antibody (ab5392) is a chicken polyclonal antibody and is validated for use in ICC/IF, IHC-P and WB.
Anti-MAP2 antibody (ab5392) was first used in a scientific publication in 2006 and has been cited over 788 times in peer reviewed journals. It's performance in IHC and Immunofluorescence in human, mouse and rat samples is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-MAP2 antibody (ab5392) has high sensitivity and specificity.
Anti-MAP2 antibody (ab5392) has 62 independent reviews from customers.
Anti-MAP2 antibody (ab5392) specifically detects MAP2 (UniProt ID: P11137; Molecular weight: 200kDa) and is sold in 25 µL selling sizes.
MAP2, a dendritic marker, plays a crucial role in Alzheimer's disease (AD) research. Researchers use MAP2 to assess dendritic integrity in AD models, making it essential for understanding neuronal structure and pathology in Alzheimer's disease.

Properties and Storage Information:
Form-Liquid, Purification notes-Lipid extraction from egg yolk, followed by ammonium sulphate precipitation., Storage buffer-Preservative: 0.032% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAP2 also known as Microtubule-associated protein 2 is a critical component in cellular mechanics. It aids in the stabilization and assembly of microtubules essential for maintaining the cytoskeleton structure. MAP2 has a molecular mass of approximately 280 kDa. It is highly expressed in the dendrites of neurons in the central nervous system. This expression pattern underlines its importance in dendritic development and maintenance. Though largely neuron-specific minor expression occurs in other tissues but with significantly less intensity.
Biological function summary
MAP2 plays a role in maintaining neuronal structure. It participates in the formation of the cytoskeleton by binding to tubulin subunits in microtubules. By doing so it supports the outgrowth of dendrites critical for synaptic connections and neuronal communication. MAP2 does not typically form part of a complex but associates dynamically with other microtubule proteins to regulate microtubule dynamics. Its role extends to influencing the morphology of neurons which impacts information processing and neurotransmission.
Pathways
MAP2 factors significantly into the regulation of the MAP kinase signaling pathway among others involving cytoskeletal remodeling. It interfaces with pathways controlled by proteins like MAP kinase affecting downstream targets involved in cellular growth and differentiation. MAP2 also interacts with tau proteins both being integral microtubule-associated proteins fostering structural support and transport within neurons.
MAP2 has a connection to neurodegenerative diseases such as Alzheimer's. Abnormal phosphorylation of MAP2 like that observed in tau leads to defective microtubule stability implicating it in neuronal dysfunction associated with Alzheimer's. Additionally some evidence points to MAP2's involvement in schizophrenia where altered dendritic morphology parallels changes in MAP2 expression. Its interaction with other microtubule-associated proteins especially tau further supports its relevance in disease pathology.