Abcam, ab54205, Anti-beta Endorphin antibody [B 31.15]

Size: 100µg
Mouse Monoclonal POMC antibody. Suitable for IHC-P, IHC-Fr and reacts with Rat, Macaque monkey, Human samples. Cited in 5 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human POMC.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:B 31.15,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, Macaque monkey, Rat,
Applications:IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human POMC.P01189

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta-endorphin a peptide hormone alternatively named 'β-endorphin' or 'b-endorphin' plays important roles in the modulation of pain and stress. It originates in the pituitary gland as a cleavage product of proopiomelanocortin (POMC). The molecular weight of beta-endorphin is approximately 3.4 kDa. This peptide is expressed in significant concentrations within the central nervous system especially in the hypothalamus and the anterior lobe of the pituitary gland. Its synthesis and release are subject to regulation by the hypothalamus which ensures precise control of its physiological actions.
Biological function summary
Beta-endorphin functions as an endogenous opioid which means it naturally binds to opioid receptors and mimics the effects of opiate drugs like morphine. It does not form part of any large protein complexes but acts independently to influence neurotransmitter activities and modulate the body's response to pain. This function underlies its activity as a natural analgesic contributing to its ability to reduce pain perception and produce feelings of well-being. Moreover it plays a part in regulating immune function stress response and even energy homeostasis by interacting with various receptors and cellular mechanisms.
Pathways
Beta-endorphin plays an important role in the endogenous opioid system which oversees critical processes related to pain modulation and reward. It links to the hypothalamic-pituitary-adrenal (HPA) axis influencing stress response pathways. Neuropeptide Y is one of the proteins associated with beta-endorphin through these pathways. Involvement in these pathways demonstrates its impact on not just nervous system functionality but also on broader physiological activities that maintain homeostasis under stress conditions.
Beta-endorphin has connections with conditions such as chronic pain syndromes and depression. Its role in managing the pain and emotional state suggests a potential therapeutic target for alleviating symptoms associated with these disorders. Additionally beta-endorphin activity can affect serotonin levels as these neurotransmitters often interplay in mood regulation and perception pathways. Understanding beta-endorphin's contribution to these pathophysiological processes allows scientists to explore potential treatment strategies involving modulation of its activity.