Abcam, ab5465, Anti-T Cell Receptor antibody [JOVI.1]

Size: 50µg
Mouse Monoclonal T Cell Receptor antibody. Suitable for IP, Flow Cyt, IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing TRBC1 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:JOVI.1,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, IP, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing TRBC1 protein. The exact immunogen used to generate this antibody is proprietary information.P01850,
Specificity:Specific to the C beta 1 chain

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azide Constituents: 99.98% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The T Cell Receptor (TCR) functions as an important part of the immune system by recognizing antigens bound to major histocompatibility complex (MHC) molecules. Commonly known as TCR this receptor is a heterodimeric protein generally composed of two transmembrane regions: the Alpha (α) and Beta (β) chains with each chain possessing a variable and constant region. The mass of the α β heterodimeric TCR approximates 75 kDa. TCRs are highly expressed on the surface of T cells which are integral components of adaptive immunity.
Biological function summary
The TCR enables T cells to identify and respond to specific pathogens supporting cell-mediated immune responses. It operates as a part of the extensive TCR complex which includes the CD3 co-receptor molecules. These co-receptors stabilize TCRs on the cell surface and help facilitate signal transduction. The antigen recognition by the TCR leads to the activation of T cells serving as an important step in the immune response.
Pathways
The TCR is central to initiating the T cell receptor signaling pathway and plays significant roles in the adaptive immune system pathway. Upon interaction with antigen-presenting cells the TCR forms a synapse leading to the activation and recruitment of kinases such as LCK and ZAP-70. These kinases are important for downstream signaling events which further lead to T cell proliferation and cytokine production.
The TCR has links to autoimmune diseases such as rheumatoid arthritis and certain cancers like T-cell leukemia. In these conditions improper TCR signaling or misrecognition of self-antigens can contribute to disease pathogenesis. Misregulated TCR activity can also engage with proteins like CTLA-4 and PD-1 now targeted by immunotherapy offering novel treatment avenues to modulate T cell responses.