Abcam, ab55716, Recombinant human Myosin IIIB protein

Size: 5µg / 10µg
Recombinant human Myosin IIIB protein is a Human Fragment protein, in the 1 to 326 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>90% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Specific Activity: 85 nmol/min/mg,
Accession:Q8WXR4,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA, 0.00174% PMSF

Product details:
ab64311
(Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Myosin IIIB also known as MYO3B is a molecular motor protein that generates movement along actin filaments. This protein has a molecular mass of approximately 136 kDa. Unlike other myosin proteins Myosin IIIB demonstrates unique mechanical properties suited for specialized functions. You primarily find it expressed in the sensory hair cells of the inner ear and retina where it plays a role in cellular transport and structural integrity.
Biological function summary
Myosin IIIB participates in intracellular transport and mechanosensory processes. It functions as part of a protein complex that includes other actin-binding proteins assisting in maintaining the precision of sensory receptor structures. Through these interactions MYO3B helps ensure the proper localization of proteins necessary for the sensory cells’ function.
Pathways
Myosin IIIB plays a significant role in sensory perception pathways and cytoskeletal rearrangement. It interacts with proteins such as actin and harmonin in the auditory pathway which is essential for hearing. Another important pathway includes visual perception where MYO3B partners with USH1C important for the structural integrity of photoreceptor cells.
Myosin IIIB alterations have links to hearing loss and vision disorders particularly Usher syndrome. This connection is partly due to interactions with proteins like harmonin and USH1C which are important in maintaining the structural organization of sensory hair cells in both the inner ear and retina. Understanding the role of MYO3B in these conditions assists in the development of targeted therapies for sensorineural deficits.