Abcam, ab55740, Anti-SHOX2 antibody [1D1]

Size: 100µg
Mouse Monoclonal SHOX2 antibody. Suitable for WB, IHC-Fr and reacts with Recombinant fragment - Human, Rat, Human samples. Cited in 24 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SHOX2 aa 100-250.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1D1,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SHOX2 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.O60902

Product details:
This product was changed from ascites to tissue culture supernatant on 16/Oct/2019. Lot numbers higher than GR3303529 are from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The short stature homeobox 2 (SHOX2) is a transcription factor protein involved in various regulatory functions. It is also known as OG12X and is characterized by its homeobox domain. SHOX2 weighs approximately 28 kDa. Its expression occurs mainly in the embryonic heart skeletal system and developing limbs. Researchers observe SHOX2 in specific adult tissues such as the sinoatrial node of the heart where it plays roles in maintaining regular cardiac rhythm.
Biological function summary
The protein influences developmental processes by regulating gene expression during embryogenesis. SHOX2 is not part of a large complex but functions independently to modulate the development of tissues and organs. It ensures proper formation of heart structures skeletal growth and limb patterning. SHOX2's absence or malfunction can lead to disruptions in the structural development of these areas.
Pathways
SHOX2 has significant roles in cardiac pacemaker and limb development pathways. It is heavily involved in the canonical Wnt signaling pathway which supports the growth and differentiation of various tissues. The relationship between SHOX2 and BMP4 another protein in this pathway is important for bone development and limb formation. SHOX2 also interfaces with T-box proteins like TBX5 contributing to the specification and function of heart tissues.
SHOX2 links to conditions such as short stature homeobox-related syndromes and congenital heart defects. Dysfunctions in SHOX2 can lead to Léri-Weill dyschondrosteosis a disorder associated with short stature and skeletal abnormalities. In heart development the interaction between SHOX2 and NKX2-5 another important transcription factor is pivotal. Abnormalities or mutations in SHOX2 may also contribute to sinus node dysfunction impacting heart rate regulation.