Abcam, ab59626, Anti-CEACAM20 antibody [HT-12D8]

Size: 100µg
Mouse Monoclonal CEACAM20 antibody. Carrier free. Suitable for Flow Cyt, ICC/IF and reacts with Transfected cell line samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:HT-12D8,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab59626 does not react with CEACAM1, CEACAM3-8 or CEACAM19-21.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab59626 was purified by protein G affinity chromatography from cell culture supernatants., Storage buffer-pH: 7.2Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEACAM20 also known as carcinoembryonic antigen-related cell adhesion molecule 20 is a member of the CEACAM family of proteins. It has a molecular weight of approximately 32 kDa. This protein is expressed mainly in epithelial tissues including in the gastrointestinal tract and lungs. Its expression is often context-dependent appearing in specific tissues during particular developmental stages or conditions. CEACAM proteins in general play roles in cell signaling and cell adhesion.
Biological function summary
CEACAM20 contributes to processes such as cell-cell communication and immune response modulation. It may form part of a larger complex with other CEACAM proteins engaging in homo- or heterophilic interactions which help mediate its role in cellular adhesion. These interactions can affect immune cell activation and the epithelial tissue integrity where it is expressed hinting at its involvement in maintaining tissue function under various physiological conditions.
Pathways
CEACAM20 plays roles in the immune response and epithelial cell signaling pathways. It interacts closely with other CEACAM family proteins such as CEACAM1 and CEACAM8 which are involved in similar pathways. These interactions likely influence the recruitment and activation of immune cells. Through these pathways CEACAM20 helps with communication between cells in the immune system and epithelial layers aiding in effective response mechanisms and barrier protection.
Increased or altered expression of CEACAM20 has been linked to inflammatory diseases and cancer. In inflammatory bowel disease its expression can impact epithelial function and immune response potentially exacerbating the condition. In cancer particularly colorectal cancer CEACAM20's interaction with proteins such as CEACAM1 could influence tumor growth and immune evasion. Understanding these interactions may provide insight into potential therapeutic targets for these conditions.