Abcam, ab5993, Anti-ANP32E antibody

Size: 100µg
Rabbit Polyclonal ANP32E antibody. Suitable for ICC, WB, IHC-P and reacts with Human, Rat samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Human ANP32E.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ANP32E. The exact immunogen used to generate this antibody is proprietary information.Q9BTT0,
Specificity:This antibody does not cross-react with PHAPI or PHAP12a.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANP32E also known as acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein with a mass of approximately 29 kDa. This protein plays an important role in chromatin remodeling and regulation of gene expression by acting as a histone chaperone. ANP32E is intensely expressed in the nuclear compartment of numerous cell types with significant presence in tissues like the brain and testis. It participates in critical cellular functions that influence DNA accessibility for transcription and replication.
Biological function summary
ANP32E is involved in chromatin dynamics within cells. As part of the INHAT (Inhibitor of Histone Acetyltransferases) complex ANP32E directly interacts with histones to modulate their acetylation status. This process impacts the way genes are presented for transcription. By regulating histone acetylation ANP32E affects gene expression patterns thereby influencing cellular processes such as proliferation and differentiation.
Pathways
ANP32E is deeply involved in the DNA damage response and chromatin modification pathways. It interacts closely with proteins like histone H2A.Z during chromatin remodeling contributing to proper DNA repair mechanisms. ANP32E also affects the cell cycle regulation through its modulation of acetylation status impacting diverse biological pathways essential for cellular function and stability.
ANP32E has significant implications for cancer and neurodegenerative diseases. In cancer ANP32E dysregulation can lead to abnormal cell proliferation and tumor progression. Its interactions with proteins involved in chromatin remodeling are critical for maintaining genomic stability which is often disrupted in oncogenesis. In neurodegenerative conditions changes in ANP32E expression or function could contribute to altered gene expression patterns associated with disease development and progression.