Abcam, ab6106, Anti-hnRNP L antibody [4D11]

Size: 100µL
Mouse Monoclonal hnRNP L antibody. Suitable for IHC-P, IP, Flow Cyt, WB and reacts with Human samples. Cited in 61 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human HNRNPL.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4D11,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human HNRNPL.P14866

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from supernatant., Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Heterogeneous nuclear ribonucleoprotein L commonly known as hnRNP L functions in the processing of pre-mRNA. It binds to RNA sequences influencing mRNA stability splicing and nuclear export. The protein weighs approximately 64 kDa and is typically expressed in a variety of human tissues including the brain and liver. hnRNP L contains RNA recognition motifs that allow dynamic interaction with RNA playing a central role in gene expression regulation.
Biological function summary
HnRNP L contributes to alternative splicing by modulating intron retention and exon skipping. It operates as a monomer but may interact with other hnRNP family members to form complexes. These complexes allow hnRNP L to exert its influence over mRNA metabolism in different cellular contexts ensuring the diverse expression of proteins necessary for various cellular functions.
Pathways
HnRNP L integrates into the mRNA splicing and transport pathways significantly affecting gene expression. It interacts with other splicing factors such as SR proteins helping to orchestrate the formation of spliceosomes. These interactions further connect hnRNP L to the pathway involving the regulation of alternative splicing choices affecting how cells respond to environmental and developmental cues.
HnRNP L shows implications in cancer and autoimmune diseases. Abnormal regulation or expression of hnRNP L has associations with tumor progression particularly influencing cancer-related genes through altered splicing patterns. Additionally hnRNP L interacts with autoimmune-related proteins such as SRSF1 which suggests its role in the pathogenesis of autoimmune conditions. Understanding these interactions provides valuable insights into potential therapeutic targets.