Abcam, ab6176, Anti-pan Synuclein antibody

Size: 100µL
Rabbit Polyclonal Alpha-synuclein antibody. Suitable for WB, IHC-P, ICC/IF, IHC-Fr and reacts with Rat, Human samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human SNCA aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat,
Applications:IHC-P, ICC/IF, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SNCA aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P37840,
Specificity:This antibody recognises all 3 forms of the synucleins.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-pH: 7 - 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Add glycerol to a final volume of 50% for extra stability and aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pan Synuclein also known as alpha beta and gamma synucleins are small proteins with molecular masses around 14-19 kDa. These proteins are expressed largely in the central nervous system and are also present in other tissues such as the peripheral nervous system and certain types of muscles. They share structural similarities and comprise a family often involved with neurons where they play roles in various cellular processes.
Biological function summary
Synucleins participate in the regulation of synaptic function and plasticity influencing neurotransmitter release and membrane dynamics. They do not form a specific complex but can interact with lipid membranes and various cellular proteins affecting vesicular transport processes. These proteins hold influence over essential cellular functions that depend on synaptic activity and efficiency.
Pathways
Synucleins involve themselves in important neuronal pathways such as those controlling dopamine neurotransmission and regulation of mitochondrial functions. They interact with key proteins like parkin and ubiquitin which participate in protein degradation pathways. Synucleins' roles in these pathways highlight their impact on both synaptic transmission and energy metabolism within neurons.
Synucleins have strong connections to neurodegenerative disorders like Parkinson's disease and dementia with Lewy bodies. In these disorders alpha-synuclein in particular forms aggregates known as Lewy bodies contributing to neuronal dysfunction. These aggregates interact with proteins such as tau and amyloid-beta further linking synucleins to the pathology of these disorders. Understanding these interactions provides insights into potential targets for therapeutic interventions.