Abcam, ab61765, Anti-Eph receptor B1 + Eph receptor B2 antibody

Size: 100µg
Rabbit Polyclonal Eph receptor B1/NET antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human EPHB1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EPHB1. The exact immunogen used to generate this antibody is proprietary information.P54762

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Eph receptor B1 and Eph receptor B2 are part of the Eph family of receptor tyrosine kinases known as EphB1 and EphB2. These receptors play significant roles in cell positioning and movement by mediating cell-to-cell interactions. EphB1 has a molecular weight of approximately 108 kDa and EphB2 weighs around 110 kDa. They are expressed in various tissues including the brain where they are involved in nervous system development and synaptic plasticity.
Biological function summary
EphB1 and EphB2 are involved in processes such as neuronal development and angiogenesis. They participate in forming signaling complexes that guide cell sorting and boundary formation. These receptors interact with ephrin-B ligands initiating bidirectional signaling that influences cellular repulsion and adhesion. Their activities are essential for maintaining proper tissue architecture and directing axon pathfinding.
Pathways
EphB1 and EphB2 integrate into the Eph-ephrin signaling pathway and distinct Rho GTPase signaling pathways. These receptors activate intracellular signaling cascades that regulate cytoskeletal dynamics. They also interact with proteins like Src family kinases which modulate signal transduction processes necessary for cell migration and axonal guidance. This signaling contributes to key biological functions like tissue development and maintenance.
EphB1 and EphB2 have associations with cancer progression and neurological disorders. Dysregulation in their signaling can lead to aberrant cell growth and contribute to the invasion of cancerous cells. Additionally alterations in EphB1 and EphB2 function have links to conditions such as Alzheimer's disease. These receptors interact with proteins like amyloid precursor protein influencing pathways that control neural health and survival. Understanding these interactions helps in developing potential therapeutic strategies for these conditions.