Abcam, ab62373, Anti-beta Dystroglycan antibody [EP2200Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DAG1 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP2200Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Dystroglycan also known as β-DG is a transmembrane protein with a molecular mass of approximately 43 kDa. It plays a mechanical role by linking the extracellular matrix to the cytoskeleton acting as a part of the dystrophin-glycoprotein complex. This protein is widely expressed in many tissues including skeletal muscle cardiac muscle and the central nervous system. Beta Dystroglycan serves as a receptor for components like laminin and agrin in the extracellular matrix.
Biological function summary
Beta Dystroglycan acts as a structural and signaling molecule within the dystrophin-glycoprotein complex. This complex stabilizes the sarcolemma during muscle contraction and helps in protecting muscle fibers from injury. Beta Dystroglycan also contributes to cellular signaling pathways by interacting with various intracellular proteins like dystrophin and alpha dystroglycan. It regulates cell adhesion and migration processes critical for tissue maintenance and repair.
Pathways
Beta Dystroglycan plays a critical role in the integrity of the dystrophin-associated glycoprotein complex. It is involved in the AKT signaling pathway which is essential for cellular growth and survival. Moreover beta Dystroglycan interacts closely with proteins such as dystrophin and utrophin facilitating their functions in muscle cells. Its interactions help maintain cell membrane stability and signal transduction processes important for normal cellular functions.
Beta Dystroglycan’s dysfunction has been closely linked to muscular dystrophies specifically Duchenne and Becker muscular dystrophies. These conditions involve muscle weakness and degeneration linked to abnormalities in the dystrophin-glycoprotein complex. Additionally aberrant glycosylation and signaling of beta Dystroglycan contribute to cancer progression through altered cell adhesion and migration often involving interactions with proteins like α-dystroglycan.