Abcam, ab64168, Anti-RREB1 antibody

Size: 50µg
Rabbit Polyclonal RREB1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Ras-responsive element-binding protein 1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Mouse Ras-responsive element-binding protein 1.Q3UH06

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: 0.87% Sodium chloride, 0.42% Tripotassium orthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RREB1 also known as Ras-responsive element-binding protein 1 is a zinc finger transcription factor with a molecular mass of approximately 197 kDa. RREB1 is highly expressed in various tissues including the pancreas lung and prostate. Its primary role involves binding to specific Ras-responsive elements (RREs) in the DNA regulating the transcription of genes that are pivotal for cell differentiation growth and apoptosis.
Biological function summary
The RREB1 protein interacts with other components to activate or repress target gene expression often acting as part of larger transcriptional complexes. It influences key biological processes such as embryonic development and cellular response to stress by controlling genes involved in these pathways. The interconnected function of RREB1 guides essential cellular decisions including how cells adapt to signaling cues in their environment.
Pathways
RREB1 significantly contributes to the Ras signaling pathway and the MAPK/ERK pathway connecting it to important cellular events like proliferation and differentiation. RREB1 functions alongside proteins such as RAS and MEK collaborating to transmit signals from the cell surface to the nucleus. Through these pathways RREB1 plays a role in adjusting cellular responses to external stimuli influencing gene expression patterns critical for diverse cell functions.
The dysregulation of RREB1 has connections to cancer including prostate and pancreatic cancers. Abnormal RREB1 function can lead to uncontrolled cell proliferation due to its role in gene expression regulation. It has interactions with proteins such as KRAS in these disorders contributing to oncogenic transformations. Additionally alterations in RREB1 are linked to diabetes mellitus where its misregulation might affect insulin signaling pathways impacting glucose metabolism and homeostasis.