Abcam, ab65147, Anti-MLX antibody

Size: 100µg
Rabbit Polyclonal MLX antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MLX.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MLX. The exact immunogen used to generate this antibody is proprietary information.Q9UH92

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MLX also known as Max-like protein is a basic helix-loop-helix leucine zipper transcription factor. It has a molecular mass of approximately 31 kDa. MLX expresses in various tissues with prominent expression in metabolic organs such as the liver. This protein is part of the larger Mondo family and interacts with other Max network transcription bHLH proteins. MLX functions as a binding partner to form heterodimers which then bind to DNA at E-box sequences to regulate gene transcription.
Biological function summary
MLX regulates cellular energy homeostasis and glucose metabolism. It partners with Mondo proteins such as MondoA to form transcriptional complexes that control the expression of glycolytic enzymes and other metabolic genes. This role is essential for cellular adaptation to changes in nutrient availability and energy demands. MLX's function influences the cell's metabolic adaptation and its overall contribution to energy balance in the body.
Pathways
MLX engages with the glucose signaling pathway and the pentose phosphate pathway. It interacts with enzymes and proteins like glucose-6-phosphate dehydrogenase through transcriptional regulation. By forming dimeric complexes MLX controls the transcriptional responses to cellular glucose levels coordinating with other transcription factors such as c-Myc. This coordination helps in maintaining metabolic homeostasis and fosters cellular growth and proliferation under varying nutrient states.
Scientists link MLX to metabolic disorders and cancer. Dysregulation of MLX-related pathways may lead to metabolic diseases such as diabetes where impaired glucose signaling is a concern. Moreover MLX's interaction with proteins like c-Myc positions it as a modifier in cancer progression as aberrant transcriptional control can drive oncogenic processes. Understanding MLX's role in these contexts aids in identifying therapeutic targets for associated diseases.