Abcam, ab65200, Anti-Rab11A antibody

Size: 100µg
Rabbit Polyclonal Rab11A antibody. Suitable for WB and reacts with Human samples. Cited in 28 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rab11A also known as Ras-related protein Rab-11A is a member of the Rab family of small GTPases. This protein has a molecular weight of about 24.7 kDa and plays an important role in the regulation of intracellular recycling pathways. Rab11A is widely expressed in various tissues including the brain liver heart and lungs. It is found on recycling endosomes where it orchestrates vesicle trafficking a process critical for maintaining cellular homeostasis.
Biological function summary
Rab11A functions in intracellular transport by regulating vesicle budding and fusion. It ensures the proper recycling of membrane proteins like transferrin receptors and integrins. Rab11A interacts with a set of effector proteins that guide vesicle movement towards specific locations within the cell. This protein can also form complexes with other proteins such as Rab11FIP1 to facilitate effective cargo delivery. The actions of Rab11A are critical in processes like cell migration and growth factor signaling.
Pathways
Rab11A plays a role in the endocytic recycling and exocytic pathways. It ensures proper trafficking from endosomes to the plasma membrane. Rab11A interacts closely with proteins like Rab5 and Rab7 setting up a sequential transport system that regulates cargo delivery between different organelles. In the recycling pathway Rab11A is important for the sorting and return of cell surface receptors to the plasma membrane helping to maintain cell surface receptor pools.
Rab11A links to cancer and neurodegenerative diseases. Altered Rab11A expression and activity can affect processes like cell proliferation and apoptosis contributing to tumorigenesis. In neurodegenerative diseases aberrant Rab11A-mediated recycling may impact neurotrophic signaling and axonal transport leading to neuronal dysfunction. Mutations or dysregulation in related proteins such as Rab11FIP further implicate Rab11A in these diseases as they can disrupt the normal physiological functions governed by Rab11A.