Abcam, ab65289, Anti-FIV p24 antibody [PAK3-2C1]

Size: 125µg
Mouse Monoclonal GAG antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC-Fr and reacts with Feline immunodeficiency virus samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:PAK3-2C1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Feline immunodeficiency virus,
Applications:ICC/IF, IHC-Fr, ELISA, Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Feline Immunodeficiency Virus (FIV) p24 protein also known as the FIV capsid protein plays a mechanical role in the assembly and stability of the viral core. It has a molecular mass of approximately 24 kDa. This protein is expressed within infected feline cells where it forms the central part of the viral capsid a structure that encapsulates the viral RNA genome and associated proteins. The proper formation of the capsid is essential for the viral particle's integrity and its ability to successfully infect host cells.
Biological function summary
The FIV p24 protein functions as a critical component of the viral capsid complex. It facilitates the encapsidation of the viral genome and interacts with other viral proteins such as reverse transcriptase and integrase during the viral life cycle. The p24 protein aids in the transport of retroviral complexes to the nucleus of the host cell. Its role in forming a solid capsid is necessary for the protection of viral genetic material and eventual release of new virions from the infected cell.
Pathways
The FIV p24 protein participates in the viral assembly and replication processes. It is involved in pathways related to the formation of the viral capsid and budding of new virions from the host cell. During these processes p24 interacts with other structural proteins like the FIV matrix protein (p15) which together ensure the successful packaging of the virus. In the context of assembly these interactions are vital for the generation of infectious viral particles.
FIV p24 protein is closely associated with feline immunodeficiency a disease similar to HIV in humans. The presence of antibodies against p24 serves as a diagnostic marker for FIV infection in cats. Additionally the immune response to p24 and its interactions with other viral proteins such as the FIV envelope glycoprotein are subjects of study in the development of potential vaccines and treatments aimed at controlling the viral infection and its progression in feline populations.