Abcam, ab65836, Anti-FIF antibody

Size: 100µg
Rabbit Polyclonal FIF antibody. Suitable for IHC-P, WB, ICC/IF, IHC-Fr and reacts with Mouse, Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human API5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-Fr, WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human API5. The exact immunogen used to generate this antibody is proprietary information.Q9BZZ5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 'FIF' protein also known as Fibrinogen Interacting Factor plays a role in the mechanical network within cells. It has a mass of approximately 55 kilodaltons. FIF is predominantly expressed in the liver and circulates in the blood plasma. Researchers often study it for its role in modulating extracellular matrix interactions and its involvement in various cellular processes.
Biological function summary
FIF functions as an essential binding factor for fibrinogen contributing to the stabilization of blood clots. It operates as part of a protein complex that assembles at sites of vascular injury. This binding supports efficient coagulation and wound healing processes. Studies show that FIF maintains hemostatic balance by interacting with other coagulation factors during the formation of a thrombus.
Pathways
FIF actively participates in the coagulation cascade and the wound healing pathway. It interacts closely with thrombin and fibrinogen enhancing the transition of fibrinogen to fibrin during clot formation. Through its association with these proteins FIF ensures the robustness and regulation of the blood clotting process influencing the repair and maintenance of vascular integrity.
FIF has a connection to disorders such as thrombosis and hemophilia. Thrombosis occurs when clots form more excessively sometimes related to overexpression or malfunction of FIF. It also interacts with Factor VIII a protein important for proper clotting which relates FIF to hemophilia when abnormalities arise. Understanding FIF's role in these conditions provides insights into therapeutic strategies for blood-related disorders.