Abcam, ab66037, Anti-AC5 antibody

Size: 100µg
Rabbit Polyclonal AC5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human Adenylate cyclase type 5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Adenylate cyclase type 5. The exact immunogen used to generate this antibody is proprietary information.O95622,
Specificity:This antibody can cross-react with ADCY6.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adenylate Cyclase 5 (AC5) is an enzyme that plays an essential role in catalyzing the conversion of ATP to cyclic AMP (cAMP). AC5 is also known as ADCY5. Its molecular weight is approximately 150 kDa. AC5 is mostly expressed in the brain and heart tissues suggesting its significant role in central and cardiovascular functions.
Biological function summary
AC5 contributes to the regulation of cAMP levels an important secondary messenger in many signaling cascades. AC5 forms part of enzyme complexes that modulate cellular responses through cAMP signaling pathways. Alteration in its activity can directly impact the regulation of neurotransmitter and hormone activity influencing processes such as learning memory and myocardial contractility.
Pathways
AC5 integrates into the cAMP-dependent signaling pathway and the adrenergic signaling pathway. It associates with other proteins like G protein-coupled receptors (GPCRs) and protein kinase A (PKA) that enhance these pathways' functions. Through its role in these pathways AC5 influences diverse physiological responses such as cardiac rhythm and neural transmission.
AC5 has a significant connection to heart failure and movement disorders such as dyskinesia. Heart failure relates to AC5 through its regulation of cardiac contractility where disruption in cAMP signaling can worsen the condition. In movement disorders like dyskinesia AC5’s connection to dopamine receptors alters the sensitivity of pathways in the brain influencing motor control and stability.