Abcam, ab67309, Anti-SLITRK5 antibody

Size: 100µg
Rabbit Polyclonal SLITRK5 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab67309 is predicted to have no cross-reactivity to other SLITRK proteins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLITRK5 also known as Slit and Trk-like family member 5 is a transmembrane protein with a mass of approximately 105 kDa. It is part of the SLITRK family which includes six members. SLITRK5 is expressed primarily in the central nervous system especially in the brain's regions like the thalamus and hippocampus. This protein is involved mechanically in axon guidance and synaptic organization playing a role in neural circuit development by influencing cell adhesion processes.
Biological function summary
SLITRK5 influences neural connectivity and synapse formation. It interacts with other molecules such as the leucine-rich repeat transmembrane 2-1 (LRRTM2) during synaptogenesis forming a complex that enhances synaptic density and maturation. SLITRK5 through these interactions assists in maintaining proper neural communication which is fundamental for processes like learning and memory. Its expression pattern suggests its potential involvement in specific brain function regulations.
Pathways
SLITRK5 engages in neural signaling pathways impacting the organization and function of neuronal networks. It is involved in the neurotrophin signaling pathway interacting with other proteins such as NTRK receptors regulating neuronal survival and differentiation. Additionally SLITRK5 participates in axon guidance pathways working alongside proteins like Slit2 and Robo receptors to ensure proper neuronal wiring and targeting within the developing nervous system.
SLITRK5 has connections to neuropsychiatric conditions such as obsessive-compulsive disorder (OCD) and Tourette syndrome. Disruptions in SLITRK5 expression or function may lead to altered synaptic connectivity contributing to the pathophysiology of these disorders. Research indicates that SLITRK5 interacts with proteins such as ELFN1 and contactin-associated protein-like 2 (CNTNAP2) which are also implicated in neurodevelopmental disorders suggesting a broader role in maintaining neuronal network stability and function.