Abcam, ab67344, Anti-SAF-B2 antibody [6F7]

Size: 50µg
Mouse Monoclonal SAF-B2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SAFB2 aa 300-400.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:6F7,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SAFB2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q14151

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAF-B2 also known as Scaffold Attachment Factor B2 is a critical protein in cellular regulation with a molecular weight of approximately 100 kDa. It is widely expressed in the nucleus of various cell types serving a role in transcriptional regulation. As a component of the scaffold/matrix attachment regions (S/MARs) it interacts with chromosomal DNA to influence gene expression. This interaction helps in organizing chromosomal structures profoundly impacting gene accessibility and transcription processes.
Biological function summary
SAF-B2 takes part in regulating transcription and RNA processing contributing to its functional versatility. It interacts with several RNA-binding proteins as part of a nuclear protein complex. These interactions suggest SAF-B2’s involvement in RNA splicing and stabilization linking it to mRNA processing pathways. The protein plays an important role in maintaining transcriptional fidelity and ensuring appropriate cellular response to varying signals.
Pathways
SAF-B2 affects transcription and mRNA processing pathways significantly. It associates with proteins like SAF-B which also participate in chromatin remodeling and gene regulation. Both proteins contribute to the regulation of gene expression through their participation in the complex network of transcriptional pathways. Additionally SAF-B2's involvement in signaling pathways indicates its broader role in cellular communication and response modulation.
Alterations in SAF-B2 have connections to cancer and neurodegenerative diseases. Aberrant expression or mutation can disrupt normal gene regulation processes contributing to tumorigenesis or neural dysfunction. The protein's interaction with SAF-B highlights the potential for misregulated pathways to promote disease states. Understanding SAF-B2’s role in these processes aids in developing targeted therapeutic strategies.