Abcam, ab67415, Anti-ELL3 antibody

Size: 50µg
Mouse Polyclonal ELL3 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RNA polymerase II elongation factor ELL3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RNA polymerase II elongation factor ELL3.Q9HB65,
Specificity:Reactive against mammalian transfected lysate.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELL3 also known as Eleven-nineteen Lysine-rich Leukemia protein 3 has a molecular weight of around 70 kDa. It functions as an elongation factor belonging to the ELL family which includes ELL and ELL2. This protein exhibits expression in various tissues but higher levels occur in testes and several cancer cell types. ELL3 enhances the process of transcription elongation by positively regulating the rate at which RNA polymerase II progresses along the DNA template allowing efficient synthesis of full-length transcripts.
Biological function summary
The protein acts as a component of the super elongation complex (SEC) which suggests its role in maintaining active transcription in cells. ELL3 contributes to the regulation of gene expression important for cell development and proliferation. This protein influences the transcriptional output of genes associated with cell cycle control and differentiation. Through the SEC it interacts with several transcription factors and co-factors that integrate various signals for effective gene expression tuning.
Pathways
ELL3 plays an essential role in transcriptional pathways that involve RNA polymerase II. The protein is critical in the transcription elongation pathway which modulates the transition from transcription initiation to productive elongation. It interacts with proteins such as EAF1 and members of the AF4/FMR2 and MYC family demonstrating its interconnection within the transcriptional machinery and signaling networks that control cellular growth and energy metabolism.
ELL3 has associations with certain types of cancers particularly prostate cancer and breast cancer. Dysregulation or altered expression of ELL3 can contribute to oncogenic processes and tumor progression. In this context ELL3's interaction with proteins like ELL and ELL2 within cancer pathways emphasizes its role in cell proliferation and survival in malignant tissues. Understanding ELL3's involvement in these diseases aids in the potential development of targeted therapies for cancer treatment.