Abcam, ab67758, Anti-FOXD3 antibody

Size: 100µL
Rabbit Polyclonal FOXD3 antibody. Suitable for ChIP, WB and reacts with Chicken samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Chicken Forkhead box protein D3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Chicken,
Applications:ChIP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Chicken Forkhead box protein D3. The exact immunogen used to generate this antibody is proprietary information.P79772

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXD3 also known as Forkhead box D3 acts as a critical transcription factor involved in gene regulation. It belongs to the forkhead family of transcription factors and possesses a DNA-binding domain characterized by a winged-helix motif. FOXD3 has a molecular mass of approximately 48 kDa. Researchers have identified its expression primarily in the cells of neural crest as well as in pluripotent stem cells like embryonic stem cells during development.
Biological function summary
FOXD3 regulates the expression of numerous genes involved in cell fate determination. It plays an important role in maintaining pluripotency and preventing differentiation. FOXD3 might form complexes with other transcription factors or cofactors to modulate gene expression. These complexes assist in the fine-tuning of genetic networks essential for early development and cellular lineage specification.
Pathways
FOXD3 integrates into signaling pathways that regulate pluripotency and differentiation such as the Wnt signaling pathway. It interacts with other proteins such as NANOG and SOX2 which contribute to maintaining stem cell identity. Through these pathways FOXD3 helps control balance between self-renewal and differentiation in pluripotent cells.
FOXD3 has associations with cancer and neurodevelopmental disorders. Mutations or dysregulation in FOXD3 expression relate to melanoma potentially through its interaction with BRAF a known oncogenic protein. Additionally FOXD3 influences neural crest development and disturbances in its function may contribute to neural crest-related disorders such as Waardenburg syndrome.