Abcam, ab67773, Anti-STAC3 antibody

Size: 50µg
Mouse Polyclonal STAC3 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human STAC3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human STAC3.Q96MF2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STAC3 also known as SH3 and cysteine-rich domain 3 is a protein with a mass of approximately 35 kDa. It performs an important mechanical role in the process of excitation-contraction coupling in skeletal muscle cells. STAC3 is expressed mainly in skeletal muscle tissues where it joins other essential proteins to ensure proper muscle function. By interacting with other key proteins in the muscle STAC3 assists in the regulation of calcium ion release which is vital for muscle contraction and performance.
Biological function summary
STAC3 functions as part of a protein complex that includes the dihydropyridine receptor (DHPR) and the ryanodine receptor (RYR1) in skeletal muscles. It serves as a linking molecule within this complex facilitating communication between these receptors. This linkage is significant for maintaining the efficiency of calcium release during muscle activation. Without proper communication aided by STAC3 the calcium signaling in muscle cells becomes impaired which can affect muscle contraction.
Pathways
STAC3 plays an important role in the ECC (excitation-contraction coupling) pathway. This pathway is critical in converting an electrical signal to a mechanical response in muscle cells. It interacts specifically with DHPR and RYR1 which are central components in this signaling process. The interaction of STAC3 with these proteins helps in coordinating the sequence of events that leads to muscle contraction and relaxation showing how STAC3 integrates into these fundamental cellular processes.
Defects in STAC3 link to congenital myopathies specifically Native American myopathy (NAM). This disorder severely affects muscle function leading to symptoms like muscle weakness and skeletal deformities. Through its relation to NAM STAC3 also connects with mutations in RYR1 which is another protein implicated in muscle disorders. Understanding STAC3's role offers potential for developing therapeutic strategies targeting this protein to alleviate muscle-associated diseases.