Abcam, ab67844, Anti-MRPL18 antibody

Size: 50µg
Mouse Polyclonal MRPL18 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MRPL18.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human MRPL18.Q9H0U6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPL18 also known as mitochondrial ribosomal protein L18 is an integral component of the mitochondrial ribosome. This protein has a molecular mass of about 21 kDa. It plays a mechanical role in the translation of mitochondrial mRNA aiding the assembly of protein synthesis machinery. MRPL18 finds expression predominantly in tissues with high energy requirements such as heart and brain.
Biological function summary
MRPL18 is essential for mitochondrial protein biosynthesis. It forms part of the 39S subunit of the mitochondrial ribosome implicating its role in the production of polypeptides catalyzed by mitochondrial DNA. By facilitating efficient translation of genetic material into functional proteins MRPL18 collaborates with other ribosomal proteins and rRNA to maintain mitochondrial function.
Pathways
MRPL18 significantly contributes to oxidative phosphorylation and energy generation pathways. It supports these pathways by translating essential components of the electron transport chain. Closely related proteins like MRPL49 and MRPS16 also participate in these pathways together ensuring effective energy transduction within the cell.
MRPL18 shows associations with mitochondrial diseases such as mitochondrial encephalomyopathy. Impaired function or mutations in MRPL18 can disrupt mitochondrial protein synthesis leading to defective energy metabolism. The target's relationship with proteins like MRPS22 highlights its involvement in disease mechanisms affecting cellular energy homeostasis.