Abcam, ab67886, Anti-ZNF331 antibody

Size: 50µg
Mouse Polyclonal ZNF331 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNF331.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ZNF331.Q9NQX6,
Specificity:This antibody is reactive against mammalian transfected lysate.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF331 also known as Zinc Finger Protein 331 is a member of the zinc finger protein family and functions as a transcriptional regulator. The protein weighs approximately 63 kDa. It carries zinc finger motifs that enable DNA binding which affects gene expression. ZNF331 frequently occurs in various tissues with higher expression levels in the spleen and lymph nodes. This suggests its role in the immune system or related physiological processes.
Biological function summary
ZNF331 acts as a transcriptional repressor influencing the regulation of target genes by binding to specific DNA sequences. It participates in regulating cell growth and apoptosis processes critical for maintaining cellular homeostasis. ZNF331 interacts with other proteins to form complexes that modulate chromatin structure affecting gene accessibility and transcription. The protein's expression pattern and molecular function indicate its involvement in tissue-specific regulatory mechanisms.
Pathways
Research shows ZNF331 participates in pathways related to cell cycle regulation and apoptotic signaling. It interacts with p53 signaling pathway components an important pathway involved in tumor suppression by triggering cell cycle arrest or apoptosis in response to DNA damage. ZNF331's interaction with such pathways implies its potential role in maintaining cellular integrity. Its related proteins such as p21 and cyclins further emphasize its function in cell cycle modulation.
Research links ZNF331 to various cancers particularly gastric and colorectal cancers. Abnormal expression patterns such as downregulation associate with tumor progression and malignancy. Additionally ZNF331 shows potential involvement in immune-mediated disorders due to its expression in lymphoid tissues. Disruption of its interaction with p53 and related proteins can exacerbate disease symptoms by permitting unchecked cellular proliferation highlighting its importance in oncogenesis and immune function.