Abcam, ab68617, Biotin Anti-HIV1 p24 antibody

Size: 500µL
Goat Polyclonal POL antibody - conjugated to Biotin. Suitable for ELISA, WB, ICC/IF and reacts with Human immunodeficiency virus samples. Cited in 1 publication.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Conjugation:Biotin,
Carrier free:No,
Reacts with:Human immunodeficiency virus,
Applications:WB, ICC/IF, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody reacts with HIV1 p24 in viral and infected tissue samples.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HIV1 p24 also known as HIV p24 protein is a core protein of the Human Immunodeficiency Virus type 1 (HIV-1). The p24 protein has a molecular weight of about 24 kDa. HIV1 p24 comprises part of the viral capsid which encases the viral RNA genome. This protein is prominently expressed during the early stages of HIV infection. The presence of HIV1 p24 is commonly detected through various laboratory techniques including the use of p24 ELISA kits.
Biological function summary
HIV1 p24 plays an important role in the viral life cycle. It assists in the formation and stability of the viral capsid which is critical for maintaining the integrity of the viral core. HIV p24 is not a lone actor; it is part of the structural framework and interacts with other viral proteins to facilitate the viral assembly and maturation processes. The detection of HIV1 p24 is a marker for viral replication and infection stage.
Pathways
The function of HIV1 p24 aligns significantly within the HIV replication pathway and the host’s immune response pathway. HIV p24 is intrinsically tied to processes of viral assembly alongside proteins like Gag and Pol coordinating to ensure successful viral replication. Furthermore the immune system recognizes the HIV1 p24 protein thereby integrating it into the host immune response which is important in disease progression and for diagnostic purposes like in the HIV ELISA assay.
HIV1 p24 is integrally connected to HIV/AIDS a disorder that profoundly affects the immune system. The presence of HIV p24 in the bloodstream is an early marker of infection and is frequently monitored to track the disease's progression. Alterations in the levels of p24 protein relate to the efficiency of therapeutic interventions. The study of HIV1 p24 also brings focus on its interaction with the CD4 receptor which is pivotal in the viral entry process further linking various stages of the HIV infection cycle to potential therapeutic targets.