Abcam, ab69458, Anti-FATP1 antibody

Size: 50µg
Mouse Polyclonal FATP1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC27A1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SLC27A1.Q6PCB7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FATP1 also known as Slc27a1 stands for Fatty Acid Transport Protein 1 and plays a significant role in fatty acid uptake and metabolism. It functions as a transporter that facilitates the influx of long-chain fatty acids across cell membranes. FATP1 weighs approximately 63 kDa and exhibits expression mainly in adipose tissue muscle and liver. The presence of FATP1 in these tissues suggests a specialized involvement in energy metabolism and storage processes.
Biological function summary
FATP1 supports critical processes in lipid metabolism and energy balance. It is not just a flexible transporter of fatty acids but also plays a role in the activation of these molecules through acyl-CoA synthetase activity. FATP1 associates with other metabolic enzymes to form functional complexes that optimize lipid utilization. Through these activities FATP1 influences cellular lipid composition and energy homeostasis with significant effects on metabolic health.
Pathways
FATP1 integrates into the intricate network of lipid metabolism and energy pathways. It is linked with the peroxisome proliferator-activated receptor (PPAR) signaling pathway which regulates lipid metabolism and glucose homeostasis. FATP1 interacts with proteins like CD36 and acyl-CoA synthetase long-chain family members enhancing its role in fatty acid uptake and contributing to efficient metabolic processes.
FATP1 shows associations with metabolic syndromes like obesity and type 2 diabetes. Its altered activity or expression contributes to impaired lipid metabolism thereby aggravating these conditions. FATP1 also has connections with proteins like insulin receptor substrate 1 (IRS1) where dysregulation affects insulin signaling pathways. Understanding FATP1's functions and interactions provides insights into potential therapeutic targets for managing metabolic disorders.