Abcam, ab69597, Anti-Adenylate cyclase 1/AC1 antibody

Size: 100µg
Rabbit Polyclonal Adenylate cyclase 1/AC1 antibody. Suitable for IHC-P, ELISA, WB and reacts with Human, Mouse samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, IHC-P, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adenylate cyclase 1 (AC1) also known as adenylate cyclase is an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP) in response to various signaling molecules. This enzyme has a molecular mass of approximately 130 kDa. AC1 is localized mainly in neurons of the central nervous system. It acts as an adenylate cyclase activator responding to signals and modulating the downstream effects via cAMP production. Forskolin is a well-known pharmacological activator of adenylate cyclases including AC1 which can elevate intracellular cAMP levels.
Biological function summary
Adenylate cyclases like AC1 play critical roles in signal transduction by regulating the intracellular concentration of cAMP a second messenger involved in numerous cellular processes. AC1 is part of a complex including G-protein coupled receptors which regulate its activity. The presence of AC1 in the brain suggests its involvement in neural signaling and neuroplasticity contributing to the modulation of synaptic transmission and the function of neuronal networks.
Pathways
Adenylate cyclase activity is integral in the cAMP signaling pathway where it mediates the effects of neurotransmitters and hormones. This pathway is important for processes such as learning and memory where cAMP acts as an important mediator. AC1 activity is linked to proteins involved in the Calcium/Calmodulin-dependent protein kinase pathway providing a bridge between calcium signaling and cAMP production which influences synaptic plasticity and neurocognitive functions.
AC1 has connections to conditions like depression and addiction where dysregulation of cAMP signaling is observed. Altered activity of AC1 can affect other proteins such as protein kinase A which plays a role in emotional and reward responses. Understanding the function of AC1 in these conditions aids in exploring potential therapeutic targets for neuropsychiatric and neurodegenerative diseases.