Abcam, ab69639, Anti-TRIM59 antibody

Size: 100µg
Rabbit Polyclonal TRIM59 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 14 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM59 also known as tripartite motif-containing protein 59 is a protein that weighs approximately 54 kDa. It belongs to the TRIM family and has a conserved RING finger domain which implies a role in ubiquitination. The protein shows expression in various tissues including the liver kidney and spleen. TRIM59 has an E3 ubiquitin ligase activity that adds ubiquitin molecules to target proteins tagging them for degradation by the proteasome. This process helps regulate protein levels and maintain cellular homeostasis.
Biological function summary
TRIM59 influences cellular processes such as proliferation apoptosis and immune response. It acts as part of a complex that participates in protein degradation and signal transduction. The protein affects cell signaling pathways by modulating the ubiquitination and turnover of key signaling molecules. Through these actions TRIM59 can influence how cells respond to external stimuli and manage their internal functions. Alterations in its activity can lead to disruptions in these processes.
Pathways
TRIM59 plays a role in the PI3K/AKT and Wnt signaling pathways. In the PI3K/AKT pathway it affects cellular survival and growth while in the Wnt signaling pathway it influences cell fate determination. TRIM59 interacts with proteins such as AKT and β-catenin which serve as important players in these pathways. These interactions enable TRIM59 to impact downstream signaling events and modulate cellular outcomes contributing to multiple physiological functions and processes.
TRIM59 has a connection with several cancers including prostate cancer and gastric cancer. Elevated levels of TRIM59 often correlate with tumor progression and poor prognosis. In prostate cancer TRIM59 interacts with the androgen receptor influencing its stability and activity. In gastric cancer it affects proteins such as p53 a well-known tumor suppressor leading to altered cell cycle regulation. The dysregulation of TRIM59 and its related pathways suggest potential targeting strategies for therapeutic interventions.