Abcam, ab69699, Anti-EXOSC5/CML28 antibody

Size: 50µg
Mouse Polyclonal EXOSC5/CML28 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EXOSC5.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human EXOSC5.Q9NQT4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EXOSC5 also known as CML28 is a core component of the exosome complex an important multiprotein machinery involved in RNA processing and degradation. EXOSC5 has a molecular mass of approximately 34 kDa and is expressed in a wide range of tissues. It functions as a scaffold within the exosome complex interacting with other exosome subunits to maintain the stability and structure of the complex.
Biological function summary
EXOSC5 is important for the normal function of the RNA exosome complex which plays a central role in 3'-to-5' RNA processing and degradation. The exosome complex is essential for removing defective RNA molecules and managing RNA stability. EXOSC5 acts as a bridge between the core exosome and additional cofactors that enhance the exosome's specific functions. This regulation ensures appropriate cellular RNA levels impacting gene expression and integrity.
Pathways
EXOSC5 is involved in the RNA surveillance pathway which monitors and degrades aberrant RNA transcripts in the cell. The pathway ensures that only properly processed RNAs are translated into proteins. Within this framework EXOSC5 interacts with RRP44 a catalytic component of the exosome bolstering its activity in degrading faulty RNAs. The balance of RNA processing and degradation that EXOSC5 supports is vital in maintaining cellular homeostasis.
Abnormalities in EXOSC5 have been linked to autoimmune diseases and cancers. Autoimmune responses may target EXOSC5 leading to disrupted RNA processing. Moreover alterations in EXOSC5 expression or function can contribute to oncogenesis by impacting the cell cycle and apoptosis. In cancers interactions between EXOSC5 and the protein p53 suggest a connection in cell survival pathways highlighting EXOSC5's potential as a therapeutic target in cancer treatments.