Abcam, ab6982, Anti-Adenovirus Type 5 antibody

Size: 100µL / 1mL
Anti-Adenovirus Type 5 antibody (ab6982) is a rabbit polyclonal antibody detecting Adenovirus Type 5 in Western Blot, ICC/IF, ELISA, Neut . Suitable for Human adenovirus 5 . - Over 80 publications - Trusted since 2001
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human adenovirus 5,
Applications:ICC/IF, ELISA, WB, FuncS (Neut/Block)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Product Specifications
Anti-Adenovirus Type 5 antibody (ab6982) is a rabbit polyclonal antibody and is validated for use in ELISA, ICC/IF, Neut, WB in human adenovirus 5 samples.
Anti-Adenovirus Type 5 antibody (ab6982) specifically detects Adenovirus Type 5 (UniProt ID: ; Molecular weight: kDa) and is sold in 100 µL and 1 mL selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-Adenovirus Type 5 antibody (ab6982) has high sensitivity and specificity.
Anti-Adenovirus Type 5 antibody (ab6982) has been cited over 85 times in peer reviewed journals and is trusted by the scientific community.
Anti-Adenovirus Type 5 antibody (ab6982) has 9 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adenovirus Type 5 also known as Ad5 is a non-enveloped virus with a double-stranded DNA genome. It is a member of the adenoviridae family which exhibits an icosahedral capsid structure and an approximate mass of 150 MDa. Adenoviruses including Type 5 target various human tissues predominantly the epithelial cells in the respiratory gastrointestinal and urinary tracts. They utilize CAR (Coxsackie and Adenovirus Receptor) for cell entry showcasing their specific interaction with host cells.
Biological function summary
Adenoviruses like Type 5 are associated with several intracellular processes and response mechanisms. Typically they are not part of a larger biological complex but interact dynamically with the host cell machinery. During the infection process Ad5 manipulates host replication and transcription pathways to facilitate its own replication subverting normal cellular controls. This action often results in the inhibition of host cell DNA synthesis while encouraging viral replication.
Pathways
The adenovirus Type 5 engages significantly with the cellular pathways regulating apoptosis and immune response modulation. It interacts with p53 and E1A proteins which are essential influencers of cell cycle control and apoptosis. Through these interactions Ad5 can modulate the host's apoptotic pathways ensuring the virus can replicate efficiently while evading immune surveillance and promoting viral persistence.
Adenovirus Type 5 is most notably linked to respiratory illnesses and conjunctivitis. In respiratory infections Ad5 exploits the immune modulation pathways resulting in inflammation and symptoms of the common cold. It can associate with other proteins like the E3 region proteins helping evade host immune responses and leading to prolonged infection or more severe symptoms. In the context of ocular infections such as conjunctivitis similar mechanisms apply whereby the adenovirus disregards normal immune clearance perpetuating the infection cycle.