Abcam, ab69857, Anti-ELOVL6/LCE antibody

Size: 100µg
Rabbit Polyclonal ELOVL6/LCE antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human ELOVL6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ELOVL6. The exact immunogen used to generate this antibody is proprietary information.Q9H5J4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELOVL6 sometimes also known as LCE functions as an enzyme involved in the elongation of long-chain fatty acids. It primarily elongates saturated and monounsaturated fatty acyl-CoAs especially those that are C16:0 and C18:0 contributing to the production of very long-chain fatty acids. This protein has a molecular mass of approximately 29 kilodaltons and exists mainly in the endoplasmic reticulum. ELOVL6 is ubiquitously expressed with notable presence in the liver adipose tissues and brain where it plays significant roles in lipid metabolism.
Biological function summary
This enzyme modifies fatty acids therefore impacting the lipid composition of cellular membranes and lipid droplets. It does not function alone; ELOVL6 works in concert with other enzymes to regulate lipid metabolism impacting energy balance and cellular signaling. The protein influences desaturation and incorporates elongated fatty acids into more complex lipid molecules which are important for membrane fluidity and function as well as hormone signaling.
Pathways
ELOVL6 participates actively in the fatty acid biosynthesis pathway and the lipid metabolic pathway. It works closely with proteins like SCD1 (stearoyl-CoA desaturase 1) enhancing fatty acid desaturation processes. ELOVL6's function in fatty acid elongation is essential for maintaining the fluidity and functionality of lipid bilayers affecting various downstream processes including energy homeostasis and inflammation.
Research links ELOVL6 to metabolic conditions like obesity and non-alcoholic fatty liver disease (NAFLD). The enzyme's role in excessive fatty acid elongation and lipid accumulation can contribute to these disorders. ELOVL6 may interact with proteins such as AMPK (AMP-activated protein kinase) which is involved in metabolic regulation and can influence disease outcomes. These interactions suggest potential therapeutic targets for metabolic diseases where modifying ELOVL6 activity could alter the progression of lipid-related disorders.