Abcam, ab6992, Anti-CTGF antibody

Size: 50µg
Anti-CTGF antibody (ab6992) is a rabbit polyclonal antibody detecting CTGF in Western Blot, IP, IHC-P, IHC-Fr, ICC/IF . Suitable for Human, Mouse, Rat, Sheep . - Over 310 publications - Trusted since 2001
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Sheep, Human,
Applications:IHC-FoFr, IHC-Fr, IHC-P, IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Ccn2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P29268

Product details:
Product Specifications
Anti-CTGF antibody (ab6992) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP, WB in human, mouse, rat, sheep samples.
Anti-CTGF antibody (ab6992) specifically detects CTGF (UniProt ID: P29268; Molecular weight: 35kDa) and is sold in 50 µg selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-CTGF antibody (ab6992) has high sensitivity and specificity.
Anti-CTGF antibody (ab6992) has been cited over 313 times in peer reviewed journals and is trusted by the scientific community.
Anti-CTGF antibody (ab6992) has 28 independent reviews from customers.
Target Information
Connective Tissue Growth Factor (CTGF), also known as CCN2 is a protein that regulates various biological process including cell proliferation and migration. CTGF influences the tumor microenvironment by promoting angiogenesis, inflammation, and activation of cancer-associated fibroblasts (CAFs). Elevated levels of CTGF have been observed in several cancers, such as pancreatic, breast, and liver cancers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 6.5Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTGF also known as Connective Tissue Growth Factor is a significant protein in the CCN family involved in regulating various cellular functions. CTGF has a molecular weight of approximately 36-38 kDa. It is highly expressed in tissues such as the skin kidney and vascular tissues. This protein is secreted and can be found in the extracellular matrix where it interacts with other cellular components to mediate its effects.
Biological function summary
Connective Tissue Growth Factor plays an important role in cell adhesion proliferation and differentiation. It operates as an independent protein but can also be part of the extracellular matrix structure. CTGF functions as a mediator in the interaction between cells and their surrounding environment influencing processes such as angiogenesis and wound healing through these interactions.
Pathways
CTGF fits into the TGF-beta and Wnt signaling pathways where it helps modulate cellular responses to external stimuli. It interacts with proteins like fibronectin and integrins within these pathways enhancing cellular communication and response. These pathways are fundamental for both development and pathological conditions showing CTGF's influence on various biological processes.
CTGF shows a strong connection with fibrosis and cancer. In fibrotic conditions the CTGF protein interacts with collagen and fibronectin leading to excessive deposition in tissues. In cancers CTGF may promote tumor progression by facilitating angiogenesis and promoting invasive behaviors in tumors. These interactions highlight CTGF's role as a target for therapeutic strategies aimed at treating these diseases.