Abcam, ab69933, Anti-ZNF148 antibody

Size: 100µg
Rabbit Polyclonal ZNF148 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human ZNF148.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF148. The exact immunogen used to generate this antibody is proprietary information.Q9UQR1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF148 also known as ZBP-89 or BFCOL1 is a zinc finger transcription factor involved in the regulation of gene expression. The protein has a molecular mass of approximately 80 kDa. It is found in a range of tissues but shows higher expression levels in the liver and colon. ZNF148 binds to the GC-rich sequences in the promoter regions thereby influencing transcriptional activities of its target genes.
Biological function summary
ZNF148 plays a role in the regulation of cell growth and differentiation. It does not form part of a multi-protein complex but interacts directly with other transcription factors and the basal transcription machinery. The protein can repress or activate transcription depending on the cellular context and specific gene target. ZNF148 has key roles in processes such as regulation of apoptosis and maintenance of tissue homeostasis.
Pathways
ZNF148 significantly impacts the Wnt signaling pathway contributing to cell proliferation and differentiation. It also has involvement in the p53 network where it regulates genes critical for cell cycle arrest and apoptosis. It involves proteins like β-catenin in the Wnt pathway and it influences the p53 protein within the cell cycle pathway.
ZNF148 has links to colorectal cancer and liver diseases. In colorectal cancer its dysregulation can affect cell proliferation and apoptosis through interactions with proteins such as β-catenin. In liver diseases alterations in ZNF148 expression impact the balance of cell survival and death with connections to the p53 protein playing an important part in liver tissue response to stress and damage.