Abcam, ab70001, Anti-Nanos3 antibody

Size: 50µg
Rabbit Polyclonal Nanos3 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat, Mouse samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human NANOS3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NANOS3. The exact immunogen used to generate this antibody is proprietary information.P60323,
Specificity:ab70001 does not cross-react with either Nanos1 or Nanos2.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nanos3 also known as NOS3 is a small RNA-binding protein with a molecular mass of approximately 22 kDa. Nanos3 plays an important role in the maintenance of germ cells. It is mainly expressed in the gonads particularly within primordial germ cells during early development. This expression is important for the formation and preservation of germ cell populations ensuring fertility and proper reproduction.
Biological function summary
Nanos3 functions as part of a protein complex that regulates mRNA stability and translation. This protein restricts apoptosis of primordial germ cells by moderating the expression of target genes. These regulatory actions are essential for maintaining both the population and integrity of germ cells. As such any impairment in its function can lead to disruptions in germ cell development.
Pathways
Nanos3 integrates into signaling pathways that are significant in the differentiation and survival of germ cells. Notably it operates within the BMP (Bone Morphogenetic Protein) signaling pathway which is responsible for germ cell maintenance. Nanos3 also interacts with other RNase proteins like PUM2 to modulate mRNA targets that are critical for cell cycle regulation and germ cell formation.
Nanos3 has links to gonadal dysgenesis and infertility. Genetic mutations or altered expression of Nanos3 can result in these reproductive disorders highlighting its importance in germ cell health. The protein is also associated with the regulation of apoptotic pathways possibly connecting it to proteins like BCL2 which is involved in preventing cell death. Understanding the role of Nanos3 can provide insights into therapies for related reproductive conditions.