Abcam, ab70208, Anti-ZBTB7A antibody

Size: 100µL
Rabbit Polyclonal ZBTB7A antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human ZBTB7A aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZBTB7A aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95365,
Specificity:We have data to indicate that this antibody may not cross react with Mouse. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZBTB7A also known as LRF or FBI-1 functions as a transcription factor and is part of the BTB-POZ domain and zinc finger protein family. It has a molecular mass of approximately 68 kDa. ZBTB7A primarily expresses in various tissues like the thymus spleen and testis where it plays a role in gene regulation. It binds to specific DNA sequences to control gene expression influencing cell differentiation and proliferation.
Biological function summary
ZBTB7A acts as a transcriptional repressor that interacts with chromatin remodeling complexes. By binding to several DNA sites it regulates genes involved in critical cellular processes including growth and apoptosis. ZBTB7A is also part of a larger complex that includes partners like BCL6 where it contributes to the regulation of immune responses and hematopoiesis.
Pathways
ZBTB7A has significant involvement in the PI3K/AKT/mTOR signaling pathway and the Wnt/β-catenin pathway. In the PI3K/AKT/mTOR pathway it interacts with proteins like AKT1 to influence cellular growth and survival and in the Wnt/β-catenin pathway ZBTB7A works with β-catenin to regulate expression of genes key to development and cell cycle progression. These roles underline its importance in the control of cellular homeostasis.
ZBTB7A has a strong association with cancer particularly in hematological malignancies and prostate cancer. It often works in conjunction with proteins like MYC enhancing oncogenic processes and tumor growth. Disruptions in ZBTB7A expression or function may also relate to immunological disorders due to its influence on immune cell regulation through interaction with proteins such as FOXP3 which plays a role in immune function.