Abcam, ab70245, Anti-DIS antibody

Size: 100µL
Rabbit Polyclonal DIS antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CCAR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CCAR1. The exact immunogen used to generate this antibody is proprietary information.Q8IX12

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to DIS immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DIS also known as the Death Inducing Signaling Complex functions as a mechanical trigger for apoptosis. A multi-protein complex the mass of DIS varies as it consists of several proteins assembling together. Located primarily in the cytoplasm it plays a significant role in cellular death programs. The expression of its components occurs widely but especially in cells undergoing stress or programmed cell death.
Biological function summary
Several proteins converge within the Death Inducing Signaling Complex to initiate apoptotic pathways. The complex includes proteins such as procaspases and adapter proteins like FADD. DIS's primary role is to recruit and activate procaspase-8 which then instigates a cascade of events leading to cell apoptosis. This process is important for maintaining cellular health and removing damaged or dangerous cells within organisms.
Pathways
DIS serves as a central hub in the extrinsic apoptotic pathway. Key proteins such as Fas receptor (CD95) and TNF receptor contribute to its activation. These receptors when bound to their ligands provide the initial step for DIS formation beginning the apoptosis signaling cascade. The involvement of DIS in the extrinsic pathway showcases its importance in controlling and regulating apoptosis efficiently.
Aberrations in the Death Inducing Signaling Complex function associate with chronic conditions and cancer. Overactive DIS signaling can contribute to excessive cell death leading to neurodegenerative diseases. Conversely impaired DIS activity may result in inadequate apoptosis allowing cancerous cells to survive longer. In these disorders interactions with proteins like FLIP are significant as it can inhibit DIS function altering the apoptosis process and impacting disease progression.