Abcam, ab70319, Anti-UBAP2L antibody

Size: 50µL
Rabbit Polyclonal UBAP2L antibody. Suitable for IP, WB and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human UBAP2L.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UBAP2L. The exact immunogen used to generate this antibody is proprietary information.Q14157

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBAP2L also known as USP10-associated protein 2-like has a molecular mass of approximately 115 kDa. Mechanically it functions as a translational regulator. This protein is enriched in cellular compartments including the cytoplasm and stress granules. It interacts with multiple proteins and is found in many tissues suggesting a role in cellular stress responses and phase separation events.
Biological function summary
UBAP2L influences stress granule dynamics and protein synthesis under stress conditions. It is important for assembly of these translationally silent granules suggesting its involvement in cell survival. As a part of a larger protein interaction complex UBAP2L contributes to cellular homeostasis. Its interaction partners include G3BP1 which serves as an important player in stress granule nucleation.
Pathways
UBAP2L integrates into the mRNA surveillance pathway and the cellular stress response pathway. It interacts with proteins like USP10 and G3BP1 to facilitate stress granule formation and disassembly critical for proper mRNA metabolism. Through these pathways UBAP2L helps maintain proteostasis under cellular stress affecting translation and decay of mRNA.
UBAP2L has implications in neurodegenerative diseases and cancer. Aberrations in its function contribute to Alzheimer's disease through dysregulated stress granule assembly involving proteins like TDP-43. Additionally it plays a role in tumor progression where alterations in its expression correlate with poor prognosis interacting with oncogenic proteins such as HNRNPA1 linked to metastasis and cellular proliferation.