Abcam, ab70890, Anti-COP1 antibody

Size: 100µL
Rabbit Polyclonal COP1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human COP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human COP1. The exact immunogen used to generate this antibody is proprietary information.Q8NHY2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COP1 also known as RING finger and WD-40 repeat-containing protein 53 or RFWD2 is an E3 ubiquitin ligase weighing approximately 85 kDa. It primarily regulates protein turnover through ubiquitylation. COP1 localizes in the nucleus and cytoplasm and influences protein stability by marking target proteins for degradation. Its known targets include transcription factors and regulatory proteins. COP1's role extends across various organisms often expressed in multiple human tissues highlighting its importance in cellular regulation.
Biological function summary
COP1 affects multiple cellular processes including the control of photoperiodic flowering and circadian rhythm in plants. In mammals COP1 associates with other proteins as part of a larger complex that regulates gene expression. It modulates cell cycle progression and impacts tumor suppressor pathways. This protein complex interaction allows COP1 to target specific substrates for ubiquitylation impacting biological functions relevant to organismal development.
Pathways
COP1 participates in the light signaling pathway and the p53 signaling pathway. In the p53 pathway COP1 targets p53 an important tumor suppressor protein for degradation. This interaction can influence the pathway's regulation impacting the cell cycle and apoptosis. COP1's involvement in these pathways illustrates its multifunctional nature and its ability to respond to environmental cues by altering cellular states and responses.
COP1 has been associated with cancer due to its regulatory role in the p53 tumor suppressing pathway. Abnormal expression or mutation of COP1 can lead to uncontrolled degradation of p53 increasing the risk of tumor development. Additionally alterations in COP1 have been implicated in metabolic disorders where it influences insulin signaling. Researchers continue to study COP1's interactions with other proteins like MDM2 another E3 ligase to better understand its role in disease modulation and potential therapeutic approaches.