Abcam, ab72027, Anti-PPP2R3B antibody

Size: 100µL
Rabbit Polyclonal PPP2R3B antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPP2R3B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PPP2R3B. The exact immunogen used to generate this antibody is proprietary information.Q9Y5P8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PPP2R3B also known as Protein Phosphatase 2 Regulatory Subunit B'' is a regulatory subunit of the protein phosphatase 2A (PP2A) complex. This protein plays a role in modulating the activity of the PP2A enzyme complex which is a critical enzyme in cell signaling. PPP2R3B has a molecular weight of approximately 57 kDa. It is expressed in various tissues with notable expression in the heart and skeletal muscle suggesting its importance in these tissues. The regulatory function of PPP2R3B involves interaction with the catalytic and scaffold subunits of PP2A.
Biological function summary
PPP2R3B influences a variety of cellular processes through its role in the PP2A complex. PP2A is involved in cell growth division and apoptosis by regulating phosphorylation states of serine and threonine residues on target proteins. As a regulatory subunit PPP2R3B can modify the specificity and localization of the PP2A complex impacting cellular signaling pathways. It does not act alone but as part of a larger protein complex it helps ensure accurate and timely signal transduction within cells.
Pathways
The activity of PPP2R3B within the PP2A complex influences the Wnt and MAPK signaling pathways. These pathways are important in regulating cell fate decisions and proliferative responses. Within the Wnt pathway PPP2R3B associates with proteins like Axin and GSK-3β influencing the stability and activity of β-catenin. In the MAPK pathway it can impact the activation state of key signaling proteins such as Raf-1 linking it with cell proliferation and differentiation.
Dysregulation of PPP2R3B has implications in cancer and cardiac disorders. In certain cancers altered expression or mutations can disrupt normal cell proliferation control contributing to tumorigenesis. The interaction of PPP2R3B with proteins such as MYC is evident in some cancer contexts as it affects MYC stabilization and function. In cardiac disorders changes in PP2A complex activity influenced by PPP2R3B can lead to improper cardiac development or function connecting it to diseases like cardiomyopathies.