Abcam, ab72044, Anti-SFRS8 antibody

Size: 100µL
Rabbit Polyclonal SFRS8 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SFSWAP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SFSWAP. The exact immunogen used to generate this antibody is proprietary information.Q12872

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab72044 was affinity purified using an epitope specific to SFRS8 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SFRS8 also known as SR protein splicing factor 8 or SFRS8 is a serine/arginine-rich splicing factor involved in the regulation of alternative splicing in pre-mRNA. The protein is approximately 81 kDa and is expressed in various tissues including the brain heart and skeletal muscle. SFRS8 functions as a splicing regulator modulating the assembly of spliceosomes through its interaction with other splicing factors and components of the messenger ribonucleoprotein complexes.
Biological function summary
SFRS8 plays key roles in the regulation of alternative splicing influencing the diversity of protein isoforms that cells can produce. It is often part of larger spliceosome complexes functioning with other serine/arginine-rich proteins to ensure accurate and efficient splicing of introns from pre-mRNAs. This regulatory capability is important for maintaining gene expression and cellular functions particularly in tissues with preferential expression like the nervous and muscular systems.
Pathways
SFRS8 integrates within the spliceosomal and mRNA processing pathways. It coordinates actions with other serine/arginine-rich splicing factors like SRSF1 and SRSF9 which participate in the splicing enhancer complexes. These pathways are essential in post-transcriptional regulation where SFRS8 helps ensure proper exon inclusion or skipping. This regulation is especially significant in pathways leading to protein diversification and cellular differentiation processes.
SFRS8 impacts several disorders including cancer and spinal muscular atrophy. Aberrations in SFRS8 expression or function can lead to defective splicing and subsequent production of abnormal protein isoforms. In cancer altered SFRS8 activity can affect cell proliferation and survival through interactions with other factors like hnRNP proteins. Similarly in spinal muscular atrophy improper splicing can disrupt the function of SMN proteins closely tied to motor neuron degeneration.