Abcam, ab72143, Anti-USP47 antibody

Size: 100µL
Rabbit Polyclonal USP47 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human USP47.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human USP47. The exact immunogen used to generate this antibody is proprietary information.Q96K76

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP47 also known as Ubiquitin Specific Peptidase 47 plays a role in deubiquitinating proteins by removing ubiquitin molecules from them. It is a member of the ubiquitin-specific proteases with a molecular mass of approximately 159 kDa. USP47 expresses widely in various tissues including the brain lungs and liver.
Biological function summary
The function of USP47 focuses on maintaining levels of key proteins that require deubiquitination. It stabilizes beta-Catenin and other regulatory proteins by protecting them from proteasomal degradation. As a part of the larger ubiquitin-proteasome system USP47 works with other deubiquitinating enzymes but forms no stable complex with them. Its action ensures the regulation of protein homeostasis impacting cell cycle progression and DNA damage response.
Pathways
USP47 interacts with the Wnt signaling pathway and the DNA damage repair pathway. By controlling the stability of beta-Catenin USP47 influences the Wnt signaling which plays a role in cell growth and differentiation. In the context of DNA repair USP47 interacts with other proteins like Flap endonuclease 1 (FEN1) to contribute to genome integrity by processing DNA lesions and maintaining genomic stability.
USP47 shows involvement with cancer and neurological disorders. Abnormal USP47 activity can lead to uncontrolled cell proliferation due to impacted beta-Catenin levels linking it to cancerous transformations. In neurological disorders USP47's effect on protein homeostasis may connect with proteins like Tau suggesting a role in neurodegenerative disorders where protein aggregation occurs.