Abcam, ab72179, Anti-TRH-R antibody

Size: 100µg
Rabbit Polyclonal TRH-R antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Thyrotropin-releasing hormone receptor aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Thyrotropin-releasing hormone receptor aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P34981

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.2% Gelatin, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRH-R also known as Thyrotropin-Releasing Hormone Receptor is a G-protein-coupled receptor specifically binding the tripeptide hormone TRH. This receptor has a molecular weight of approximately 70 kDa. It is express in high levels in the anterior pituitary gland as well as the central nervous system and various peripheral tissues. TRH-R plays a mechanical role in mediating the effects of TRH which include stimulating the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary.
Biological function summary
The TRH-R is involved in important physiological processes. The binding of TRH to TRH-R initiates a cascade of intracellular events leading to the activation of phospholipase C and the subsequent production of inositol triphosphate and diacylglycerol. This signaling pathway elevates intracellular calcium levels and ultimately modulates the secretion of hormones like TSH. TRH-R does not form part of a larger complex but relies on interaction with heterotrimeric G proteins to exert its effects.
Pathways
TRH-R is significantly involved in the hypothalamic-pituitary-thyroid axis. Upon activation by TRH TRH-R activates signaling pathways that regulate thyroid hormone levels playing a role in metabolism. It also interacts with other receptors such as somatostatin receptors which can modulate the inhibitory effects on hormone secretion processes.
The dysregulation of TRH-R function has links with conditions like hypothyroidism and hyperprolactinemia. In these disorders the altered signaling of TRH-R influences the levels of important hormones such as TSH and prolactin. TRH-R connects with thyrotropin and prolactin-related proteins which serves as both diagnostic markers and potential therapeutic targets in these diseases.